This is my hypothesis on how to treat and prevent EGID, based on stuff I have read in the biomedical literature.
1. Create an anti-inflammatory environment.
- Adding helminths back to the intestines. We evolved wtih them over thousands of years and it’s only in the last century they have been removed. They activate Treg cells, calm dendritic cells, and stimulate alternatively activated macrophages.
- Adding in probiotics. Perhaps even fecal transplant if good donor could be found. Also including consuming organic soil. Plenty of research showing difference in gut flora of those fed formula vs. breastfed, and the differences in allergy between the two populations. Also research showing antibiotics weaken the immune system via the inflammasome. And exposure to dirt prevents allergy, while clean living leads to allergy.
- Adequate Vitamin D levels. Vitman D affects every cell in our bodies and plenty in the literature to show it has a profound effect on the immune system. Along with excessive hygiene, we are spending too much time inside.
- Eliminating allergic triggers. This would include going on an allergy elimination diet (if you were able to identify the triggers), elemental formula, allergen coverings on mattresses/pillows. Any way it would be possible to get to a baseline of lowering inflammation
- Omega 6: omega 3 balance. Finding a more evolutionary friendly balance of omega 6 to omega 3 fats, along with getting sufficient fats in the diet.
- Eliminating carbs. Especially high fructose corn syrup, which is inflammatory. If possible either a paleo, SCD or GAPS diet.
- Adequate sleep. Sleep deprivation is pro-inflammatory. Excess light at night blocks melatonin production, so turning out the lights or wearing blue-blocking glasses would be one way to help this. A melatonin supplement might be tried.
- Stress reduction. Stress will add to the inflammatory burden. Stress has been shown to affect white blood cells, for example natural killer cells. The best thing is to avoid stressful situations. For the youngsters, this might mean homeschooling. For adults, it might mean going on disability. Adding in fun is also important. Healing touch. These things are underestimated in medicine.
2. Immunotherapy for allergic sensitization.
- Sublingual immunotherapy (SLIT) is the most gentle and safe form of allergen immunotherapy that has proven efficacy. Good for seasonal allergies. For foods, can bring people to a level where they can tolerate exposures to foods while sometimes falling short of functional tolerance.
- Oral immunotherapy (OIT) would probably best be started after reaching a maintance dose with SLIT. This can get many of the people in the studies to a dose where they can consume the problem food.
- I do not think subcutaneous immunotherapy (SCIT or allergy shots) is safe or effective enough for people with EGID.
So I would first address the inflammation, and then the allergies. In experimental animal models, oral exposure to allergen in the absence of inflammation or an adjuvant leads to tolerance.